Level of 14-3-3 (Eta) Protein in Rheumatoid Arthritis Patients

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects synovial membrane 14-3-3η (eta) novel protein marker showing potential in predicting radiographic deterioration early and established RA. The goal of this work was to estimate serum level 14-3-3 RA cases its association with disease activity.
 Methods: This study carried out on 50 25 apparently healthy volunteers. were classified into group A: (diagnosed within the first three years from onset disease), B: twenty-five for more than disease) (C) control group: All subjected measurements of. erythrocyte sedimentation rates (ESR) -1st hr -2nd hr, anti-cyclic citrullinated antibody (Anti-CCP), eta activity. Radiological assessment by sharp/van der hedje scored (SHS), pain estimated visual analogue scale (VAS) activity DAS 28.
 Results: There positive between ptn all clinical data (DAS 28, MHAQ, number tender joints, swollen joints VAS) both groups (A B). radiological score B).
 Conclusions: higher cases' controls. Adding test either RF or ACPA improved their diagnostic capability Predicting shows promise. Up - regulation proteins are linked adverse consequences. cases.